3-(Trifluoromethoxy)phenyl isocyanate

3-(Trifluoromethoxy)phenyl isocyanate - Names and Identifiers

Name	Benzene, 1-isocyanato-3-(trifluoromethoxy)-
Synonyms	3-(TrifluoroMethoxy)phenyl isocyate 3-(TrifluoroMethoxy)phenyl isocyanate 3-(Trifluoromethoxy)phenyl isocyanate 1-isocyanato-3-(trifluoromethoxy)benzene Benzene, 1-isocyanato-3-(trifluoromethoxy)-
CAS	55225-86-0

3-(Trifluoromethoxy)phenyl isocyanate - Physico-chemical Properties

Molecular Formula	C8H4F3NO2
Molar Mass	203.12
Storage Condition	Room Temprature

3-(Trifluoromethoxy)phenyl isocyanate - Introduction

Benzene, 1-isocyanato-3-(trifluoromethoxy)-, also known as trifluoromethoxybenzene isocyanate, is an organic compound. Its chemical formula is C8H4F3NO2 and its structural formula is OCN-C6H4-OCHF3. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: colorless liquid
-Molecular weight: 193.12g/mol
-Boiling Point: 158-159°C
-Density: 1.43g/cm³
-Melting point:-67°C
-Solubility: Soluble in organic solvents, slightly soluble or insoluble in water
-The main risk: eye and skin irritation, may lead to allergic reactions

Use:
- Benzene, 1-isocyanato-3-(trifluoromethoxy)-is an important intermediate compound, often used in organic synthesis.
-It can be used to synthesize compounds with pharmaceutical activity, such as pesticides and pharmaceutical fields.
-In materials science, Benzene, 1-isocyanato-3-(trifluoromethoxy)-can also be used in the manufacture of coatings, polymers and adhesives.

Preparation Method:
Benzene, 1-isocyanato-3-(trifluoromethoxy)-is usually prepared by synthetic chemical methods. Specific steps can include:
1. In the presence of a base, trifluorocresol and monochloromethyl formamide are reacted to generate trifluoromethoxyformate.
2. Then, the generated trifluoromethoxyformate is reacted with aniline to generate m-trifluoromethoxyaniline.
3. Finally, m-trifluoromethoxyaniline is reacted with a carbonic anhydride (e. g., carbonic anhydride) and an organic base to form Benzene, 1-isocyanato-3-(trifluoromethoxy)-.

Safety Information:
- Benzene, 1-isocyanato-3-(trifluoromethoxy)-Irritating, avoid contact with skin, eyes and respiratory tract.
-During use, attention should be paid to protective measures, such as wearing protective gloves, protective glasses and protective masks.
-In case of inadvertent contact or inhalation, wash the affected area immediately and seek medical advice.

Please note that when using chemical substances, correct operating procedures and safety measures must be followed to ensure the safety and health of personnel.

Last Update：2024-04-09 21:00:56